A. Toth

Pathogen genomic surveillance as a scalable framework for precision phage therapy

This paper develops a scalable framework for precision phage therapy by combining genomic surveillance and phage typing to target carbapenem-resistant Acinetobacter baumannii.

Genome-wide transcriptional silencing and mRNA stabilization allow the coordinated expression of the meiotic program in mice

The paper quantifies transcriptional dynamics in mouse spermatogonia during meiosis, identifying a transcriptional slowdown and mRNA stabilization event that coordinates meiotic gene expression.

Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes

The paper identifies IHO1-HORMAD1 as essential for seeding the meiotic DSB machinery on chromosome axes, ensuring sufficient DSBs for homologous chromosome pairing in mice.

Hypoxia-inducible factor (HIF) activation promotes osteogenic transition of valve interstitial cells and accelerates heart valve calcification in chronic kidney disease (CKD)

Computational and structural insights into the pre- and post-hydrolysis states of bovine multidrug resistance associated protein 1 (MRP1)

This study uses molecular dynamics simulations to analyze structural changes in bMRP1 before and after hydrolysis, revealing conformational shifts and lipid interactions.

Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scale

This study investigates the structure and function of hOAT1 using molecular dynamics simulations, identifying substrate binding sites and allosteric mechanisms involving lipid interactions.

On the interplay between lipids and asymmetric dynamics of an NBS degenerate ABC transporter

This study investigates the role of lipids and asymmetric dynamics in the NBS degenerate ABC transporter MRP1 using molecular dynamics simulations, finding limited lipid impact on transport kinetics.

Insights into the structure and function of the human organic anion transporter 1 in lipid bilayer membranes

This study presents the first robust model of hOAT1 in outward-facing conformation using protein-threading and MD simulations, revealing structural and functional insights into its transport mechanism.

TRPV1 in arteries enables a rapid myogenic tone

This study identifies TRPV1 as essential for rapid myogenic tone in heart and skeletal muscle arteries, showing TRPV1 antagonists reduce tone and that TRPV1 mediates stretch-induced Ca2+ signaling and vasoconstriction.

Directed evolution reveals the mechanism of HitRS signal transduction in Bacillus anthracis

This study uses genetic selections to uncover the molecular mechanism of the HitRS signal transduction system in Bacillus anthracis, identifying key residues and interactions essential for TCS function.

TRPV1 expressed throughout the arterial circulation enables inflammatory vasoconstriction

This study identifies TRPV1 expression in vascular smooth muscle and demonstrates its role in inflammatory vasoconstriction and systemic blood pressure regulation.

ANKRD31 regulates spatiotemporal patterning of meiotic recombination initiation and ensures recombination between heterologous sex chromosomes in mice

This study identifies ANKRD31 as essential for meiotic recombination timing and spatial organization, particularly in sex chromosomes, leading to segregation failure in its absence.

ATR is a multifunctional regulator of male mouse meiosis

This study identifies ATR as a multifunctional regulator of male mouse meiosis by showing its roles in synapsis, recombination, and chromosome axis maintenance.