Cell BiologybioRxivPreprint
A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4
S. Gumusderelioglu, L. Resch, T. Brock…·D. A. Starr
The paper identifies a KLC4 variant linked to Hereditary Spastic Paraplegia and tests its effects in a humanized C. elegans model, showing early lethality and nuclear migration defects in homozygous variants.
DOI 10.1101/2023.01.07.523106