BiochemistrybioRxivPreprint
A revised 1.6 Å structure of the GTPase domain of the Parkinson’s disease-associated protein LRRK2 provides insights into mechanisms
Chun-Xiang Wu, Jingling Liao, Yangshin Park…·Quyen Q. Hoang
This paper reports a 1.6 Å crystal structure of the GTPase domain of LRRK2, revealing how PD-associated mutations at Arg-1441 impair nucleotide-dependent conformational dynamics.
DOI 10.1101/676627