R. A. Ihrie

This paper develops GBMdeconvoluteR, a tool to accurately infer neoplastic and immune cell proportions in bulk glioblastoma RNAseq data, validated against imaging mass cytometry.

This study identifies a novel mTORC1-independent multipolar mitotic division phenotype in TSC2 mutant iPSCs, suggesting non-canonical functions of mutant TSC2.

This study shows that glioblastomas contacting the lateral ventricle have distinct immune features, including elevated T cell checkpoint receptors and suppressive myeloid cells, suggesting new therapeutic targets.

This paper introduces RAPID, an unsupervised machine learning algorithm that identifies single cell phenotypes and assesses clinical risk stratification in glioblastoma patients using single cell mass cytometry data.