Tumor-educated monocytes suppress T cells via adenosine and depletion of adenosine in the tumor microenvironment with adenosine deaminase enzyme promotes response to immunotherapy
O. S. Sarkar, H. Donninger, N. Al Rayyan, L. C. Chew, B. Stamp, X. Zhang, A. Whitt, C. Li, M. Hall, R. A. Mitchell, A. Zippelius, J. Eaton, J. A. Chesney, K. Yaddanapudi
This study shows that tumor-educated monocytes suppress T cells via adenosine and that depleting adenosine with PEG-ADA enhances immunotherapy response in preclinical models.
bioRxiv · Jun 22, 2022 · PreprintCell Biology