Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression
R. K. S. Malireddi, R. Bynigeri, B. Kancharana, B. R. Sharma, A. R. Burton, S. Pelletier, T.-D. Kanneganti
The paper generates a new IL-1α knockout mouse line (Il1a-KOline2) that maintains normal IL-1β expression, revealing IL-1's independent role in neutrophil chemoattractant production.
bioRxiv · Sep 21, 2022Cell Biology