T.-D. Kanneganti

The paper shows that SLC46A2 transports DAP-muropeptides to activate NOD1 in keratinocytes, and methotrexate inhibits this transport, reducing psoriatic inflammation.

The paper generates a new IL-1α knockout mouse line (Il1a-KOline2) that maintains normal IL-1β expression, revealing IL-1's independent role in neutrophil chemoattractant production.

This study shows that limited Caspase-1 cleavage in hepatocytes reduces pyroptosis and cytokine maturation, impairing malaria control, and that enhancing ASC expression improves immune response.

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.

This study identifies the Z2 domain of ZBP1 as critical for influenza-induced PANoptosis and perinatal lethality in mice.

This paper shows that a destabilizing HA mutation in H1N1 influenza virus reduces replication and pathogenicity in mice by enhancing type I interferon responses in dendritic cells.