Cell BiologybioRxiv
Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression
R. K. S. Malireddi, R. Bynigeri, B. Kancharana…·T.-D. Kanneganti
The paper generates a new IL-1α knockout mouse line (Il1a-KOline2) that maintains normal IL-1β expression, revealing IL-1's independent role in neutrophil chemoattractant production.
DOI 10.3389/fimmu.2022.1068230