R. C. Wek

This study identifies eIF4E1 as a key regulator of Toxoplasma gondii latency by showing its role in translational control during encystation.

This study shows GCN2 kinase supports prostate cancer growth by maintaining amino acid homeostasis, and a GCN2 inhibitor effectively reduces tumor growth in mouse models.

This study identifies TgIF2K-B as an eIF2α kinase in Toxoplasma gondii that mitigates oxidative stress and supports pathogenicity by enabling cyst formation and resisting macrophage activation.

This study shows Toxoplasma gondii triggers the unfolded protein response in host cells to enhance migration and dissemination of infected cells through IRE1-mediated actin remodeling.

This study uses ribosome profiling to analyze gene expression changes in Toxoplasma gondii and infected human cells, revealing translational control mechanisms and host response differences.