Cell BiologybioRxivPreprint
A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans
B. Vanderperre, A. Muraleedharan, M.-F. Dorion…·E. A. Fon
This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.
DOI 10.1101/2023.09.29.560170