EXTRACELLULAR PERINEXAL SEPARATION IS A PRINCIPAL DETERMINANT OF CARDIAC CONDUCTION
W. P. Adams, T. B. Raisch, Y. Zhao, R. Davalos, S. Barrett, D. R. King, C. B. Bain, K. Colucci, G. A. Blair, A. J. Lozano, A. L. Hanlon, R. Veeraraghavan, X. Wan, I. Deschenes, J. Smyth, , S. Poelzing
This study investigates the relationship between cardiac conduction velocity and extracellular space structure, finding a biphasic relationship with perinexal separation, supporting ephaptic coupling over gap junction-based conduction.
bioRxiv · May 25, 2023Biophysics