Cell BiologybioRxivPreprint
MLF2 modulates phase separated nuclear envelope condensates that provoke dual proteotoxicity
S. M. Prophet, A. J. Rampello, R. F. Niescier…·C. Schlieker
The paper identifies MLF2 as a catalyst of phase separation in nuclear envelope blebs that causes dual proteotoxicity by stabilizing ubiquitinated proteins and sequestering chaperones in DYT1 dystonia.
DOI 10.1101/2021.10.26.465916