Affinity-engineered human antibodies detect celiac disease gluten pMHC complexes and inhibit T-cell activation
R. Frick, L. S. Hoydahl, I. Hodnebrug, S. Kumari, G. Berntsen, J. R. Jeliazkov, K. S. Gunnarsen, T. Frigstad, E. S. Vik, K. E. A. Lundin, S. Yaqub, J. Jahnsen, J. J. Gray, L. M. Sollid, I. Sandlie, G. A. Loset
The paper describes the engineering of high-affinity human antibodies that recognize gluten epitopes bound to HLA-DQ2.5 and inhibit T-cell activation in celiac disease.
Science Immunology · Aug 10, 2021Peer-reviewedImmunology