A gut commensal protist protects against virus-mediated loss of oral tolerance
M. Siller, Y. Zeng, L. M. Sanchez, P. H. Brigleb, K. A. Sangani, M. Rana, L. Van Der Kraak, S. P. Pandey, M. J. Bender, B. Fitzgerald, L. Hedden, K. Fiske, G. M. Taylor, S. A. Rahman, H. J. Galipeau, , R. Hinterleitner
This study identifies the protist Tritrichomonas arnold as a protector against virus-induced loss of oral tolerance to gluten, showing it reduces inflammation in dendritic cells and is underrepresented in celiac disease patients.
bioRxiv · Jun 21, 2022Immunology