J. Das

Modelling mental disorders in zebrafish. Neurexins severely modulate anxiety, social behaviours and aggression.

This study generates zebrafish neurexin gene knockouts and identifies paralog-specific behavioral changes linked to anxiety, social behavior, and aggression, mirroring human psychiatric disorders.

Spleen Tyrosine Kinase (SYK) negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy

This study shows that SYK negatively regulates NK cell signaling and that its deletion enhances CD19-CAR NK cell efficacy in cancer immunotherapy.

Role of VapBC4 toxin-antitoxin system of Sulfolobus acidocaldarius in heat stress adaptation

This paper characterizes the VapBC4 toxin-antitoxin system in Sulfolobus acidocaldarius, showing its role in heat stress adaptation through persister cell formation and biofilm regulation.

Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes

This paper introduces a reagentless electrochemical method using self-assembled monolayers to detect small molecules in biological fluids.

Altered DNA methylation pattern contributes to differential epigenetic immune signaling in the upper respiratory airway of COVID-19 patients

This study identifies altered DNA methylation patterns in the upper respiratory airway of COVID-19 patients, highlighting changes in immune-related genes and potential implications for airway health.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

The Northern Colours: Isolation and Characterisation of 4 Pigment-Producing Bacteria from the Arctic

This study isolates and characterizes four pigment-producing bacteria from Arctic stone samples for potential pharmaceutical and industrial applications.

Impact of IL-21 on Natural Killer cell proliferation and Function - a mathematical and functional assessment

The paper assesses the impact of IL-21 on NK cell proliferation and function using mathematical and functional approaches, finding synergy between STAT3 and NF-κB and optimal IL-21 use in the priming phase.

Does novelty influence foraging decision of a scavenger?

This study tests whether free-ranging dogs prefer novel over familiar food sources, finding they inspect novel objects first, suggesting neophilia aids foraging in human-dominated environments.

Spatial organization and stochastic fluctuations of immune cells impact clinical responsiveness to immune checkpoint inhibitors in patients with melanoma

The paper develops a spatially resolved model to show how immune cell organization and dynamics influence response to immune checkpoint inhibitors in melanoma patients.

From the Wild to the City: How Domestication and Urbanization Reshape Animal Gut Microbiome

This review examines how domestication and urbanization alter gut microbiomes in animals, comparing their effects on microbial communities and ecological implications.

Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

This study quantifies how clonal stochasticity in NK cell responses to MCMV arises from proliferation and death dynamics of mature NK subsets.

Temporal dynamics and genomic programming of plasma cell fates

This study identifies a novel PC transition state and shows that long-lived plasma cells arise from late-phase GC responses through TIGIT-dependent clonal expansion.

An inimitable proprotein convertase subtilisin kexin-9 (PCSK9) cleavage site VFAQ on Spike protein along with furin cleavage site makes SARS-CoV-2 unique

The paper identifies a novel PCSK9 cleavage site in SARS-CoV-2 Spike protein and suggests its combination with the furin site contributes to the virus's uniqueness in pathogenicity and drug development.

Connexin 43 mediated collective cell migration is independent of Golgi orientation

This study shows that Connexin 43 promotes collective cell migration by reducing Golgi reorientation, independent of directed secretory trafficking.

Stability and heterogeneity in the anti-microbiota reactivity of human milk-derived Immunoglobulin A

This study examines the reactivity of breast milk-derived IgA against the infant microbiota, finding inter-donor heterogeneity and intra-donor stability in anti-bacterial IgA responses.

A gut commensal protist protects against virus-mediated loss of oral tolerance

This study identifies the protist Tritrichomonas arnold as a protector against virus-induced loss of oral tolerance to gluten, showing it reduces inflammation in dendritic cells and is underrepresented in celiac disease patients.

Probing the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy

This study investigates the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy and finds that cytoplasmic MMC is not a sensor for volume regulation, while membrane tension is critical.

The Olfm4-defined human neutrophil subsets differ in proteomic profile in septic shock

This study identifies proteomic differences between Olfm4-high and Olfm4-low neutrophil subsets in humans, suggesting distinct roles in sepsis pathogenesis.

NAC1 Modulates Autoimmunity by Suppressing Regulatory T Cell- Mediated Tolerance

This study shows NAC1 suppresses regulatory T cell-mediated tolerance by deacetylating and destabilizing FoxP3, leading to autoimmunity, and suggests targeting NAC1 could treat autoimmune disorders.

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

The paper identifies antibody responses against non-canonical and endemic coronavirus antigens as predictors of favorable outcomes in severe COVID-19.

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature

This study identifies CD4+CCR6+ T cells as key drivers of the BCG-induced transcriptional response, showing similar immune signatures across individuals.

Network-based integration of epigenetic landscapes unveils molecular programs underlying human T follicular helper cell differentiation

The paper integrates epigenomic data with a protein interactome to identify molecular programs driving human Tfh cell differentiation and links these to immune signaling in severe COVID-19.

Expression of GRINA Correlates with Prognosis in Human Cancers: A Pan-cancer Analysis

This study shows GRINA expression is upregulated in multiple cancers and linked to poor patient survival, with potential regulatory mechanisms identified through network and pathway analysis.

Bifurcated monocyte states are predictive of mortality in severe COVID-19

The paper identifies bifurcated monocyte states in severe COVID-19 patients that predict mortality, with distinct cytokine and interferon gene modules associated with survival or death.

Leaf Aqueous Extract of Manilkara hexandra influenced Glucose Metabolism in fish: An observation with Labeo rohita Fingerlings as model organism

This study investigates the hypoglycaemic effect of Manilkara hexandra leaf extract on glucose metabolism in Labeo rohita fingerlings by analyzing enzyme activities and serum glucose levels.

A naturalistic environment to study natural social behaviors and cognitive tasks in freely moving monkeys

This paper describes a naturalistic environment for training monkeys on cognitive tasks while freely moving, enabling study of brain activity during natural behaviors.

Reagentless Biomolecular Analysis Using a Nanoscale Molecular Pendulum

This paper introduces a reagentless sensor that detects molecular analytes in biological fluids by measuring directional diffusion of a nanoscale molecular pendulum and electron-transfer kinetics.

Conversion of a defensive toxin-antitoxin system into an offensive T6SS effector in Burkholderia

The paper shows Burkholderia converts defensive toxin-antitoxin systems into offensive T6SS effectors to kill co-habiting bacteria.

Thermodynamic impacts of combinatorial mutagenesis on protein conformational stability: precise, high-throughput measurement by Thermofluor

The paper uses Thermofluor to measure the thermodynamic effects of combinatorial mutations on TrpRS stability, showing strong agreement with computational models and CD melting profiles.