Y. Zeng

Foamy microglia link oxylipins to disease progression in multiple sclerosis

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

Engineering PEG10 assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

This paper develops ePAC, a cancer vaccine using PEG10-based virus-like particles to deliver neoantigens and adjuvants, showing efficacy in preclinical models.

Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

Human Amniotic Epithelial Cells Promote Chx10-/Pax6+ Muller Glia Subpopulation Reprogramming into Photoreceptor-like Cells

This study identifies a specific Muller glia subpopulation that can be reprogrammed into photoreceptor-like cells through transplantation of human amniotic epithelial cells.

DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases

This study demonstrates that DNA origami vaccine nanoparticles enhance both humoral and cellular immune responses against infectious diseases like SARS-CoV-2, HIV, and Ebola.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

Coevolution-induced stabilizing and destabilizing selection shapes species richness in clade co-diversification

This study investigates how coevolution-induced stabilizing and destabilizing selection influences species diversification in clade co-diversification, showing contrasting effects on dependent and independent clades.

Cellular protein painting for structural and binding sites analysis via lysine reactivity profiling with o-phthalaldehyde

This paper introduces RAPID-OPA, a method for intracellular protein labeling and structural analysis, identifying ligand-binding sites and conformational changes in cells.

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota

This study shows ASB3 worsens inflammatory bowel disease by destabilizing TRAF6 and altering gut microbiota, suggesting ASB3 inhibition could be a therapeutic strategy.

Micro-circulating hyperdynamic blood flow as a key pathogenic factor in early sepsis

This study identifies micro-circulating hyperdynamic blood flow as a universal pathogenic mechanism in early sepsis, leading to oxygen exchange disorder and hypoxia through the Bernoulli effect.

Data-driven prediction of colonization outcomes for complex microbial communities

The paper predicts colonization outcomes of exogenous microbes in complex communities using a data-driven approach, validated with synthetic data and experimental tests.

Self-supervised denoising for structured illumination microscopy enables long-term super-resolution live-cell imaging

The paper introduces a self-supervised denoising method for structured illumination microscopy that enables high-quality super-resolution imaging with reduced fluorescence.

Rice OsHAK18 mediates shoot-to-root circulation of potassium and sodium and source-to-sink transport of soluble sugar

Rice OsHAK18 mediates shoot-to-root potassium and sodium circulation and source-to-sink sugar transport, improving potassium use efficiency and grain yield.

Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics

This paper introduces a single-shot 3D photoacoustic tomography method using a single-element detector to enable ultrafast hemodynamics imaging in humans and small animals.

Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

Excess PrPC inhibits muscle cell differentiation via miRNA-enhanced liquid-liquid phase separation implicated in myopathy

Natural methylation epialleles correlate with gene expression in maize

The paper examines gene body methylation patterns in maize and finds a weak positive correlation between gene body methylation and gene expression, with notable exceptions in endosperm.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase

This study identifies BTRC as an E3 ligase that promotes ATGL proteasomal degradation, contributing to hepatic steatosis in NAFLD, and suggests BTRC as a potential therapeutic target.

GSK-3484862 targets DNMT1 for degradation in cells

This paper shows that GSK-3484862 targets DNMT1 for degradation in cancer cells and mouse embryonic stem cells, leading to DNA hypomethylation without reducing DNMT1 mRNA levels.

Export of discarded splicing intermediates requires mRNA export factors and the nuclear basket

This study shows that discarded lariat splicing intermediates are exported from the nucleus using the same machinery as mRNAs, requiring Mex67p, Nab2p, Yra1p, Nlp3, Mlp1p, and Tom1p.

An Open Microfluidic Coculture Model of Fibroblasts and Eosinophils to Investigate Mechanisms of Airway Inflammation

This paper introduces an open microfluidic coculture model of fibroblasts and eosinophils to study bidirectional signaling in airway inflammation, showing proinflammatory fibroblast activation and potential eosinophil feedback.

Individual tree-based vs pixel-based approaches to mapping forest functional traits and diversity by remote sensing

This study compares tree-based and pixel-based remote sensing approaches for mapping forest functional traits and diversity, finding that tree-based methods better capture trait variation at high resolution.

Epidermal threads reveal the origin of hagfish slime

This study identifies epidermal threads in hagfish skin as the evolutionary origin of slime threads, showing they are ancestral and structurally distinct from slime threads.

Cell wall extensin arabinosylation is required for root directional response to salinity

The paper identifies a genetic locus associated with root bending in response to salinity, showing that extensin arabinosylation is required for directional root responses to salt.

A gut commensal protist protects against virus-mediated loss of oral tolerance

This study identifies the protist Tritrichomonas arnold as a protector against virus-induced loss of oral tolerance to gluten, showing it reduces inflammation in dendritic cells and is underrepresented in celiac disease patients.

Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer

This study integrates multi-omic and phenotypic data to predict therapeutic response in leukemia and ovarian cancer, identifying biomarker profiles and mechanisms of resistance.

Beyond winglets: evolutionary scaling of flight-related morphology in stick insects (Phasmatodea)

This study examines flight-related morphological scaling in stick insects, showing how wing shape, mass, and muscle distribution change with wing size and flight capability.