Blocking Gi/o-coupled signaling eradicates cancer stem cells and sensitizes breast tumors to HER2-targeted therapies to inhibit tumor relapse
C. Lyu, Y. Ye, R. J. Weigel, S. Chen
This study shows targeting Gi/o-GPCR signaling eradicates cancer stem cells in HER2+ breast cancer and enhances HER2-targeted therapies to prevent tumor relapse.
bioRxiv · Feb 5, 2022Cancer Biology