Y. Ye

Physical constraints and biological regulations underlie universal osmoresponses

The paper develops a theory integrating physical constraints and biological regulations to explain universal osmoresponses in microorganisms, predicting growth thresholds and growth rate changes under osmotic stress.

The Rhizobial effector NopT targets Nod factor receptors to regulate symbiosis in Lotus japonicus

The paper shows that the rhizobial effector NopT interacts with Nod factor receptors NFR1 and NFR5 in Lotus japonicus to regulate symbiosis by cleaving NFR5 and being counteracted by NFR1 phosphorylation.

Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

The paper introduces MEMORY, a method to identify GEARs associated with cancer prognosis, finding mitosis-related genes in LUAD and immunity-related genes in BRCA.

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

This study shows that reducing glucose supply during infection improves survival in preterm infants by decreasing inflammation and maintaining normoglycemia, with liver involvement in these protective effects.

Mechanical Force Imprints Neutrophils to Orchestrate Pulmonary Homeostasis

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

The paper determines the structures of EHEP and akuBGL to elucidate how EHEP protects akuBGL from phlorotannin inhibition.

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

Fingering instability accelerates population growth of an expanding cell collective

This study uses a continuum model to show that fingering instability in cell collectives accelerates population growth through positive feedback.

Single-Cell Map of Dynamic Multicellular Ecosystem of Radiation-Induced Intestinal Injury

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

Structure of the ISW1a complex bound to the dinucleosome

The paper reports the cryoEM structure of the ISW1a complex bound to the dinucleosome, revealing its mechanism of nucleosome spacing and organization.

Translating Membrane Geometry into Protein Function: Multifaceted Membrane Interactions of Human Atg3 Promote LC3-Phosphatidylethanolamine Conjugation during Autophagy

This study determines the solution structure of human Atg3 and shows how its dynamic regions and membrane interactions facilitate LC3-PE conjugation during autophagy.

SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum

The paper identifies SAYSD1 as a sensor of ribosome UFMylation that facilitates TAQC by interacting with the translocon and UFM1 to degrade stalled proteins, maintaining ER homeostasis.

Curvature Sensing and Membrane Remodeling of the VPS37A N-terminal Domain during Autophagy

This study identifies two hydrophobic motifs in VPS37A that bind curved membranes, essential for autophagosome biogenesis.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

Allosteric Inhibition of the T Cell Receptor by a Designed Membrane Ligand

This paper tests the allosteric model of TCR activation by designing a membrane ligand that inhibits TCR signaling, supporting the model and suggesting therapeutic applications.

CircRNA-regulated immune response of Asian honey bee workers to microsporidian infection

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

Ubiquitin-based pathway acts inside chloroplasts to regulate photosynthesis

The paper shows the ubiquitin-proteasome system targets proteins inside chloroplasts, including chloroplast-encoded photosynthesis subunits, via the CHLORAD pathway.

Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells

This study investigates how different routes of self-amplifying mRNA vaccination affect the establishment of pulmonary resident memory T cells in mice.

Biochemical Characterization of a Fungal Bifunctional Type I Diterpene Synthase Brings a Cryptic Natural Product to Light

The paper identifies a tnd biosynthetic cluster in Aspergillus flavipes and characterizes a bifunctional diterpene synthase, leading to the discovery of talarodiene and its transformation into talaronoid C.

Trophoblast and blood vessel organoid cultures recapitulate the role of WNT2B in promoting intravillous vascularization in human intrauterine and ectopic pregnancy

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

The paper investigates the structure of insulin granule cores and shows that their size reduction in type-2 diabetes correlates with impaired insulin secretion.

Staphylococcus aureus nt5 gene contributes to bacterial infection ability to form kidney abscess

This study shows that silencing the nt5 gene in Staphylococcus aureus reduces kidney abscess formation and enhances phagocytosis by host immune cells.

Blocking Gi/o-coupled signaling eradicates cancer stem cells and sensitizes breast tumors to HER2-targeted therapies to inhibit tumor relapse

This study shows targeting Gi/o-GPCR signaling eradicates cancer stem cells in HER2+ breast cancer and enhances HER2-targeted therapies to prevent tumor relapse.

Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation

This study identifies RHBDL4 as a rhomboid protease that promotes retrotranslocation of aggregation-prone proteins for degradation, working with the erlin ERAD complex.

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

Mitoxantrone modulates a glycosaminoglycan-spike complex to inhibit SARS-CoV-2 infection

This study shows Mitoxantrone inhibits SARS-CoV-2 infection by targeting the spike-GAG complex, but also affects nucleosome dynamics.

Combined use of Candida Utilis and Idesia polycarpa var. Vestita Fruit Improve the Production Performance of Laying Quail

This study evaluates the effect of Idesia polycarpa fruit residues fermented feed additive on laying quail egg production and related performance metrics, finding improved egg production, reduced cholesterol, and enhanced lipid metabolism.

Programmable RNA base editing with a single gRNA-free enzyme

This paper introduces a gRNA-free RNA editing system called REWIRE that achieves high editing efficiency and low off-target effects in human and mouse cells.

Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated CSPα mutants causes lipofuscin accumulation

This study identifies two distinct roles of CSP in protein quality control, showing that dysfunction leads to lipofuscin accumulation and neurodegeneration in a Drosophila model.

Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy

This study shows that blocking Gi/o-GPCR signaling inhibits HER2-driven breast cancer growth and improves HER2-targeted therapy effectiveness.