Evolutionary BiologybioRxiv
Systematic humanization of the yeast cytoskeleton discerns functionally replaceable from divergent human genes
R. K. Garge, J. M. Laurent, A. H. Kachroo, E. M. Marcotte
The paper humanizes yeast cytoskeletal genes with human duplicates to assess functional redundancy and divergence, finding only a few human genes can replace yeast orthologs in essential functions.
DOI 10.1534/genetics.120.303378