Cancer BiologybioRxiv
ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation
P. Przanowski, R. K. Przanowska, M. J. Guertin
This study identifies ANKLE1 as a causal gene in the chr19p13.1 locus associated with cancer risk, showing it promotes apoptosis resistance and metabolic dysregulation through mitochondrial DNA cleavage.
DOI 10.1038/s42003-023-04611-w