Development of Enterovirus anti-viral agents that target the viral 2C protein
R. Kejriwal, T. Evans, J. Calabrese, L. Swistak, L. Alexandrescu, M. Cohen, N. Rahman, N. Henriksen, R. C. Dash, K. Hadden, N. J. Stonehouse, D. J. Rowlands, N. J. Kingston, M. Hartnoll, S. Dobson, S. White
This study develops broad-spectrum anti-viral compounds targeting the conserved EV 2C protein, showing low IC50 values and suggesting a role for 2C in capsid assembly.
bioRxiv · Oct 6, 2022Pharmacology & Toxicology