T. Evans

The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization

This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.

Opposite-sex associations are linked with annual fitness, but sociality is stable over lifetime.

The paper examines how social associations affect annual and lifetime fitness in birds, finding short-term benefits but long-term stabilizing selection on sociality.

Development of Enterovirus anti-viral agents that target the viral 2C protein

This study develops broad-spectrum anti-viral compounds targeting the conserved EV 2C protein, showing low IC50 values and suggesting a role for 2C in capsid assembly.

An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle

This study identifies HCN ion channels as evolutionarily conserved pacemakers in smooth muscle, showing their role in peristalsis and pacemaker activity in the urinary tract.

Transoceanic voyages of drywood termites (Isoptera: Kalotermitidae) inferred from extant and extinct species

This study uses phylogenetic analysis to infer the transoceanic dispersal history and foraging evolution of Kalotermitidae termites, finding that dispersal and human activity shaped their global distribution.

Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed

The paper tracks expansion of HPV-specific T cells in blood and cervix after a therapeutic vaccine, using bulk and single-cell sequencing.

Replay as structural inference in the hippocampal-entorhinal system

The paper proposes a dual-systems model of the hippocampal-entorhinal system, explaining grid cell firing patterns and replay through probabilistic inference and message passing between place cells.

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

Pyocin efficacy in a murine model of Pseudomonas aeruginosa sepsis

This study evaluates pyocin efficacy in a murine model of Pseudomonas aeruginosa sepsis, finding both pyocins reduce mortality and show in vivo activity.