Cell BiologybioRxiv
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds
I. Saha, P. Yuste-Checa, M. da Silva Padilha…·M. S. Hipp
This study shows that the AAA+ chaperone VCP disaggregates Tau fibrils and generates seeding-active Tau as a byproduct, suggesting a role in aggregate removal and spreading in tauopathies.
DOI 10.1038/s41467-023-36058-2