Deciphering the tumor-specific immunopeptidome in vivo with genetically engineered mouse models
A. M. Jaeger, L. E. Stopfer, E. Sanders, D. Sandel, W. Freed-Pastor, W. Rideout, S. Naranjo, T. Fessenden, P. S. Winter, R. Kohn, J. Schenkel, S.-L. Shanahan, A. K. Shalek, S. Spranger, F. White, T. Jacks
This paper uses genetically engineered mouse models to isolate and profile tumor-specific MHC-I peptides in vivo, revealing post-translational shaping of the immunopeptidome and novel tumor-associated antigens in lung adenocarcinoma.
bioRxiv · Jun 30, 2021 · PreprintCancer Biology