S. Spranger

Lung cancer-intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg-dependent CD8+ T cell exclusion

This study identifies SOX2 expression in lung cancer cells as a mechanism causing resistance to checkpoint blockade by promoting Treg-dependent CD8+ T cell exclusion.

Differentiation and Expansion of Tumor-Infiltrating T Cell Clonotypes Occurs in the Spleen Following Immune Checkpoint Blockade

This study identifies spleen-resident intermediate-exhausted T cells as key to ICB efficacy, showing their expansion and differentiation into tumor-infiltrating clonotypes.

Decoupled neoantigen cross-presentation in tumors with high intratumor heterogeneity reduces dendritic cell activation to limit anti-tumor immunity

This study shows that clonal neoantigen expression enhances dendritic cell activation and anti-tumor immunity, while subclonal expression reduces it in tumors with high intratumor heterogeneity.

Deciphering the tumor-specific immunopeptidome in vivo with genetically engineered mouse models

This paper uses genetically engineered mouse models to isolate and profile tumor-specific MHC-I peptides in vivo, revealing post-translational shaping of the immunopeptidome and novel tumor-associated antigens in lung adenocarcinoma.

Cell lineage as a predictor of immune response in neuroblastoma

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

The paper shows that increased NAD+ demand relative to ATP demand drives aerobic glycolysis by impairing NAD+ regeneration and promoting fermentation.

Development of Human Neuroblastomas in Mouse-Human Neural Crest Chimeras

This study develops a mouse-human neural crest chimera model to study human neuroblastoma development and immune interactions in vivo.