Author

A. M. Jaeger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

S. Naranjo· 4 shared T. Jacks· 4 shared A. K. Shalek· 2 shared P. S. Winter· 2 shared A. A. Borah· 1 shared A. Bhutkar· 1 shared A. D. Cherniack· 1 shared A. DenAdel· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersCancer Biology

S. Naranjo

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Author profile →

5 papers

Recent·Most cited

Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

G. Gaglia, M. Burger, C. C. Ritch, D. Rammos, Y. Dai, G. E. Crossland, S. Z. Tavana, S. Warchol, A. M. Jaeger, S. Naranjo, S. Coy, A. Johnson, R. Krueger, J.-R. Lin, H. Pfister, , S. Santagata

The paper maps lymphocyte interactions in lung adenocarcinoma using spatial analysis and machine learning, revealing dynamic lymphocyte networks that support anti-tumor immune responses.

bioRxiv · Aug 11, 2022Cancer Biology

Multiscale profiling of enzyme activity in cancer

A. P. Soleimany, J. D. Kirkpatrick, C. S. Wang, A. M. Jaeger, S. Su, S. Naranjo, Q. Zhong, C. M. Cabana, T. Jacks, S. Bhatia

This paper develops methods to measure enzyme activity in cancer across multiple scales, revealing protease dysregulation and dynamic interactions between tumor cells and their microenvironment.

bioRxiv · Nov 11, 2021 · PreprintBioengineering

Mismatch repair deficiency is not sufficient to increase tumor immunogenicity

P. M. K. Westcott, F. Muyas, O. Smith, H. Hauck, N. J. Sacks, Z. A. Ely, A. M. Jaeger, W. M. Rideout, A. Bhutkar, D. Zhang, M. C. Beytagh, D. A. Canner, R. T. Bronson, S. Naranjo, A. Jin, , T. Jacks

This study shows that MMRd in mouse tumor models does not increase immunogenicity or ICB response, due to intratumoral heterogeneity.

bioRxiv · Aug 24, 2021 · PreprintCancer Biology

Deciphering the tumor-specific immunopeptidome in vivo with genetically engineered mouse models

A. M. Jaeger, L. E. Stopfer, E. Sanders, D. Sandel, W. Freed-Pastor, W. Rideout, S. Naranjo, T. Fessenden, P. S. Winter, R. Kohn, J. Schenkel, S.-L. Shanahan, A. K. Shalek, S. Spranger, F. White, T. Jacks

This paper uses genetically engineered mouse models to isolate and profile tumor-specific MHC-I peptides in vivo, revealing post-translational shaping of the immunopeptidome and novel tumor-associated antigens in lung adenocarcinoma.

bioRxiv · Jun 30, 2021 · PreprintCancer Biology

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

S. Raghavan, P. S. Winter, A. W. Navia, H. L. Williams, A. DenAdel, R. L. Kalekar, J. Galvez-Reyes, K. E. Lowder, N. Mulugeta, M. S. Raghavan, A. A. Borah, K. S. Kapner, S. A. Vayrynen, A. Dias Costa, R. W. S. Ng, , A. K. Shalek

This study identifies a transitional cancer cell state in metastatic pancreatic cancer and shows that tumor microenvironment signals drive transcriptional plasticity and subtype transitions.

bioRxiv · Aug 25, 2020 · PreprintCancer Biology