T. Jacks

Inhalable point-of-care urinary diagnostic platform

This paper introduces a point-of-care diagnostic platform for lung cancer using inhalable nanosensors that detect tumor-associated proteases through urine analysis.

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis

This study uses single-cell spatial transcriptomics and optimal transport analysis to reveal therapy-induced changes in pancreatic cancer microenvironment interactions.

Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

The paper maps lymphocyte interactions in lung adenocarcinoma using spatial analysis and machine learning, revealing dynamic lymphocyte networks that support anti-tumor immune responses.

Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform

This study develops a reliable alveolar type 2 organoid platform to model diverse genetic subtypes of lung adenocarcinoma in vitro and in vivo.

Multiscale profiling of enzyme activity in cancer

This paper develops methods to measure enzyme activity in cancer across multiple scales, revealing protease dysregulation and dynamic interactions between tumor cells and their microenvironment.

Lineage Recording Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution

The paper tracks tumor evolution in a mouse model using lineage tracing and single-cell RNA-seq, revealing plasticity, fitness-associated programs, and stereotypical evolutionary trajectories.

Mismatch repair deficiency is not sufficient to increase tumor immunogenicity

This study shows that MMRd in mouse tumor models does not increase immunogenicity or ICB response, due to intratumoral heterogeneity.

Deciphering the tumor-specific immunopeptidome in vivo with genetically engineered mouse models

This paper uses genetically engineered mouse models to isolate and profile tumor-specific MHC-I peptides in vivo, revealing post-translational shaping of the immunopeptidome and novel tumor-associated antigens in lung adenocarcinoma.

Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice

This study measures CTC kinetics and metastatic potential by exchanging blood between tumor-bearing and healthy mice, finding short CTC half-life and high shedding rates.

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

NINJA: an inducible genetic model for creating neoantigens in vivo

The paper develops a genetic model called NINJA to create inducible neoantigens in mice, enabling controlled T cell responses without central tolerance.

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

This study shows obesity accelerates pancreatic cancer by altering the tumor microenvironment, with reversible effects through weight loss.

Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression

The paper identifies IL-33 as a driver of tumor immunosuppression by analyzing longitudinal single-cell RNA-Seq data of regulatory T cells in a mouse model of lung adenocarcinoma.

Noninvasive lung cancer detection via pulmonary protease profiling

This study uses activity-based nanosensors to detect early-stage lung cancer in mice with high sensitivity and specificity through urinary readouts of protease activity.