MicrobiologybioRxivPreprint
Amotosalen is a bacterial multidrug efflux pump substrate potentially affecting its pathogen inactivation activity
A. B. Green, K. E. Zulauf, K. A. Truelson…·J. E. Kirby
The paper investigates whether amotosalen, a psoralen used in pathogen inactivation, is a substrate for bacterial multidrug efflux pumps, finding it is pumped out by RND systems in E. coli and Acinetobacter baumannii, potentially reducing its inactivation efficacy against multidrug-resistant pathogens.
DOI 10.1101/2021.03.15.435562