M. Cui

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

Protein disulfide isomerase disassembles stress granules and blocks cytoplasmic aggregation of TDP-43 in ALS

This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.

Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

This study develops a HSV-vectored therapeutic vaccine that reactivates SIV latency and elicits immune responses, delaying viral rebound in SIV-infected macaques.

Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in normal and human mitochondrial disease models

This study identifies bacterial muropeptides as activators of ATP synthase, improving mitochondrial function and reducing stress in human cells and mice.

Glabridin induces paraptosis-like cell death via ER stress in breast cancer cells

This study shows glabridin induces paraptosis-like cell death in breast cancer cells by causing ER stress and mitochondrial dysfunction.

Highly efficient multiplex genome editing in dicot plants using improved CRISPR/Cas systems

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

Optogenetic operated probiotics to regulate host metabolism by mimicking enteroendocrine

The paper develops an optogenetic probiotics system to control enteroendocrine hormone secretion in vivo, demonstrating improved glucose control in animal models.

Angiocrine IGFBP3 Spatially Coordinates IGF Signaling During Neonatal Cardiac Regeneration

The paper identifies IGFBP3 as a secreted protein that spatially coordinates IGF signaling to promote neonatal cardiac regeneration.

Characterization of glucosyltransferase and glucuronosyltransferase family members reveals how major flavone glycoside accumulate in the root of Scutellaria baicalensis

The paper identifies key glucosyltransferase and glucuronosyltransferase enzymes in Scutellaria baicalensis and shows how SbUGAT4 contributes to the high accumulation of baicalin in root tissues.

Injectable Progranulin-derivative Atsttrin loaded Protein Engineered Gels for Post Traumatic Osteoarthritis

This paper develops a protein-based gel that delivers Atsttrin to prevent post-traumatic osteoarthritis in a rabbit model.

High resolution ultrasonic neural modulation observedvia in vivo two-photon calcium imaging

This study develops a dual-modality system to investigate high-frequency ultrasound's effect on neuronal activity in awake mice, achieving 100-micron spatial resolution.

Amotosalen is a bacterial multidrug efflux pump substrate potentially affecting its pathogen inactivation activity

The paper investigates whether amotosalen, a psoralen used in pathogen inactivation, is a substrate for bacterial multidrug efflux pumps, finding it is pumped out by RND systems in E. coli and Acinetobacter baumannii, potentially reducing its inactivation efficacy against multidrug-resistant pathogens.

Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses

The paper identifies novel bat coronaviruses, including relatives of SARS-CoV-2, from a region in China, providing insights into their evolutionary origins and geographic distribution.

PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates

This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.

Clear optically matched panoramic access channel technique (COMPACT) for large-volume deep brain imaging

The paper introduces COMPACT, a technique that significantly increases tissue access volume for deep brain imaging, enabling multiregional calcium imaging of deep brain functions associated with sleep.

The genome analysis of Tripterygium wilfordii reveals TwCYP712K1 and TwCYP712K2 responsible for oxidation of friedelin in celastrol biosynthesis pathway

This study identifies two CYP450 genes responsible for oxidizing friedelin to polpunonic acid in the celastrol biosynthesis pathway of Tripterygium wilfordii.

Sort-purification of human CD34+CD90+ cells reduces target cell population and improves lentiviral transduction

This study compares CD34+CD90+ cell purification to other HSC-enrichment strategies, showing it reduces target cells but improves lentiviral transduction and engraftment.

A novel antiviral lncRNA EDAL shields a T309 O-GlcNAcylation site to promote EZH2 degradation

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.

Winner(s)-take-all: nonlinear amplification of DNA-encoded library

This paper develops a winner(s)-take-all method for nonlinear amplification of DNA-encoded libraries, demonstrating its application in decoding DNA-encoded chemical libraries.

Degradation of miR-466d-3p by JEV NS3 facilitates viral replication and IL-1β expression

This study identifies miR-466d-3p as a target of JEV NS3 that regulates IL-1β and viral replication through miRNA degradation.

A draft reference genome sequence for Scutellaria baicalensis Georgi

The paper reports a draft reference genome sequence for Scutellaria baicalensis using Illumina and PacBio sequencing, providing a foundation for studying its bioactive compound biosynthesis.

Fungal polysaccharopeptides reduce obesity by richness of specific microbiota and modulation of lipid metabolism

This study shows that fungal polysaccharopeptides reduce obesity through microbiota-dependent and -independent mechanisms, including increasing Akkermansia muciniphila abundance and modulating lipid metabolism.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.