Cancer BiologybioRxivPreprint
Overexpression of TopBP1 leads to transformation with a TP53 mutation of non-tumorigenic breast epithelial cells
This study shows that overexpressing TopBP1 in non-tumorigenic breast cells leads to cellular transformation and tumorigenic properties, including TP53 mutation and EMT-like features.
DOI 10.1101/2022.04.05.487132