Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase.
R. F. Ortiz-Meoz, L. Wang, R. Matico, A. Rutkowska, M. De la Rosa, S. Bedard, R. Midgett, K. Strohmer, D. Thomson, C. Zhang, M. Mebrahtu, J. Guss, R. Totoritis, T. Consler, N. Campobasso, , G. Zhang
This study compares two IDO1 inhibitors, showing GSK5628 selectively inhibits apo-IDO1 by competing with heme, while epacadostat binds to the heme cofactor, leading to longer-lasting inhibition.
bioRxiv · May 7, 2020Biochemistry