D. Taylor

Data Driven Taxonomy for Antipsychotic Medication: A New Classification System

This paper develops a data-driven classification system for antipsychotics based on receptor affinity and side effect prediction using clustering and machine learning.

Molecular signatures of alternative fitness strategies in a facultatively social hover wasp

The paper analyzes transcriptomic data from a facultatively social hover wasp to compare molecular signatures of reproductive and non-reproductive castes, finding distinct gene expression patterns linked to foraging effort and reproductive strategies.

Heat stress does not induce wasting symptoms in the giant California sea cucumber (Apostichopus californicus)

This study tests if heat stress alone causes wasting in sea cucumbers, finding no such symptoms despite stress responses and mortality in some treatments.

Dead infant carrying by chimpanzee mothers in the Budongo Forest

The paper documents instances of chimpanzee mothers carrying dead infants for extended periods, suggesting potential psychological responses to death.

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

The paper identifies somatostatin venom analogs from fish-hunting cone snails, showing their potential as therapeutic leads for pain, cancer, and endocrine disorders.

One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases - Utah and Wisconsin, 2020

This study investigates SARS-CoV-2 infection and seropositivity in pets from households with confirmed human COVID-19 cases, finding that 17% of pets had neutralizing antibodies and suggesting transmission from humans to pets.

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes

Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps

This study identifies systemic tissue and cellular disruption from SARS-CoV-2 infection using autopsy and spatial omics data, showing tissue-specific damage and transcriptional changes.

Tracking the stochastic growth of bacterial populations in microfluidic droplets

The paper presents a microfluidic device and imaging protocol to track stochastic bacterial growth in droplets, finding early growth statistics align with the Bellman-Harris model.

High transgene expression is associated with systemic GFP silencing in Nicotiana benthamiana

This study shows that high transgene expression in Nicotiana benthamiana enables systemic gene silencing, while a partial transposase sequence does not affect this process.

Distinct cryo-EM Structure of α-synuclein Filaments derived by Tau

This study reports a cryo-EM structure of α-synuclein filaments promoted by tau, revealing distinct conformations compared to in vitro filaments.

Cyto-nuclear linkage disequilibrium resulting from admixture

The paper investigates cyto-nuclear linkage disequilibrium in Silene latifolia populations, attributing it to admixture from genetically differentiated European populations.

Population history and the differential consequences of inbreeding and outcrossing in a plant metapoplation

The paper examines how population history affects the relationship between inbreeding and fitness in Silene latifolia, finding that historically isolated populations show inbreeding advantages and outbreeding depression.

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

The paper screens a compound library to identify antimalarial compounds active against multiple Plasmodium life stages and transmission-blocking agents.

Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis

Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase.

This study compares two IDO1 inhibitors, showing GSK5628 selectively inhibits apo-IDO1 by competing with heme, while epacadostat binds to the heme cofactor, leading to longer-lasting inhibition.

Enabling Precision Medicine via standard communication of NGS provenance, analysis, and results

The paper introduces the BioCompute framework to standardize genomic data reporting, enabling reproducibility and interoperability in precision medicine.

Aberrant splicing in B-cell acute lymphoblastic leukemia

The paper identifies widespread aberrant splicing in pediatric B-ALL, showing that splicing factor deregulation drives splicing changes and contributes to disease.