BiophysicsbioRxiv
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor
A. Escobedo, B. Topal, M. B. A. Kunze…·X. Salvatella
This study investigates how polyglutamine tract length affects the structure and function of the androgen receptor, revealing hydrogen bonds that stabilize a helical conformation linked to transcriptional activity and disease.
DOI 10.1038/s41467-019-09923-2