J. Aranda

Double-stranded RNA induces retinal pigment epithelium cell degeneration and inflammation

This study shows dsRNA triggers RIG-I signaling, leading to inflammation and RPE degeneration in AMD, with implications for pathogenesis.

Proton Transfers to DNA in Native Electrospray Ionization Mass Spectrometry: A QM/MM Study.

This paper uses QM/MM simulations to study proton transfer mechanisms in DNA during native electrospray ionization mass spectrometry, revealing complex hydration and droplet size-dependent behavior.

A glutamine-based single α-helix scaffold to target globular proteins

This paper introduces a method to design peptides that fold into single α-helices using glutamine side chain to main chain hydrogen bonds, enabling targeted interactions with globular proteins.

Dissecting Succulence: Crassulacean Acid Metabolism and Hydraulic Capacitance are Independent Adaptations in Clusia Leaves

This study examines the relationship between succulence, CAM, and hydraulic capacitance in Clusia leaves, finding they are independent traits with distinct roles in drought tolerance.

RNA-Dependent RNA Polymerase From SARS-CoV-2. Mechanism Of Reaction And Inhibition By Remdesivir.

This study investigates the mechanism of SARS-CoV-2 RdRp reaction and Remdesivir inhibition using computational methods, finding that Remdesivir is incorporated into RNA and later leads to inhibition through a Pinners reaction.

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor

This study investigates how polyglutamine tract length affects the structure and function of the androgen receptor, revealing hydrogen bonds that stabilize a helical conformation linked to transcriptional activity and disease.