Cancer BiologybioRxiv
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
R. Delaine-Smith, E. Maniati, B. Malacrida…·F. R. Balkwill
The paper models how TGFβR and Hh pathways regulate ECM molecules in ovarian cancer using tri-culture models and identifies inhibitor combinations that reduce fibroblast activation and ECM remodeling.
DOI 10.1016/j.isci.2021.102674