Author

O. M. Pearce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Petrone· 1 shared A. S. Kashyap· 1 shared A. Zippelius· 1 shared B. Kasenda· 1 shared B. Malacrida· 1 shared C. R. Bertozzi· 1 shared D. E. Sanin· 1 shared E. L. Pearce· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

A. Petrone

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2 papers

Recent·Most cited

ImmunologyScience Translational MedicinePeer-reviewedNov 2, 2022

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

M. A. Stanczak, N. R. Mantuano, N. Kirchhammer…·H. Laeubli

This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.

DOI 10.1126/scitranslmed.abj1270

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivFeb 1, 2021

Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

R. Delaine-Smith, E. Maniati, B. Malacrida…·F. R. Balkwill

The paper models how TGFβR and Hh pathways regulate ECM molecules in ovarian cancer using tri-culture models and identifies inhibitor combinations that reduce fibroblast activation and ECM remodeling.

DOI 10.1016/j.isci.2021.102674

humanbulk RNA-seq

𝕏 PostBluesky