Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
Q. Deng, R. Natesan, F. Cidre-Aranaz, S. Arif, Y. Liu, R. Rasool, P. Wang, Z. Cramer, M. Chou, C. Kumar-Sinha, K. Weber, K. Eisinger-Mathason, N. Grillet, T. G. P. Grunewald, i. a. asangani
The paper identifies a 32-gene signature specific to Ewing sarcoma and shows that LOXHD1, a stereociliary protein, is a key driver of malignancy through its regulation by EWSR1-FLI1.
bioRxiv · Feb 22, 2021Cancer Biology