Q. Deng

Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects

This study identifies how X-linked gene dosage affects human primordial germ cell-like cell (hPGCLC) specification, revealing species-specific roles of SOX2 and SOX17 influenced by escape genes.

Cancer Cachexia in STK11/LKB1-mutated NSCLC is Dependent on Tumor-secreted GDF15

This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.

SlSAURs, targeted by SlSTOP1, inhibit SlPP2C.Ds to modulate H+-ATPase and tomato root elongation under aluminum stress

This study identifies SlSAURs as regulators of root elongation under aluminum stress by interacting with SlPP2C.Ds to modulate H+-ATPase activity.

WildPose: A Long-Range 3D wildlife motion capture system

WildPose enables long-range 3D motion capture of wildlife for ecological and biomechanical studies, demonstrating accurate tracking and morphological analysis in field trials.

Defining the contribution of Troy-positive progenitor cells to the mouse esophageal epithelium.

This study identifies Troy-positive progenitor cells in the mouse esophageal epithelium and shows how Troy regulates their fate decisions and tissue homeostasis.

Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming

This study investigates how maternal androgen exposure affects placental development in a PCOS-like mouse model and identifies trophoblast dysfunction as a key mechanism.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

Molecular basis for Gβγ-mediated activation ofphosphoinositide 3-kinase γ

This study identifies two distinct Gβγ binding sites on PI3Kγ and shows how Gβγ activates the enzyme through conformational changes and allosteric control.

A novel simian adenovirus vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens

This paper evaluates a novel simian adenovirus vectored COVID-19 vaccine, showing that intranasal vaccination induces stronger mucosal immunity while intramuscular vaccination enhances systemic immunity, with combined regimens providing long-term protection.

Temporal colonization of the gut microbiome in neonatal Bos taurus at single nucleotide resolution

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

Early microbial intervention reduces diarrhea while improves later milk production in newborn calves

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells

This study identifies a Golgi-dependent pathway involving Arf1 and Sec71 that regulates microtubule growth and reactivates quiescent neural stem cells in Drosophila.

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

RORA regulates neutrophil migration and activation in zebrafish

This study identifies miR-99 and ROR as regulators of neutrophil migration and anti-microbial defense in zebrafish.

Immune microenvironment subtypes and association with tumor cell mutations and antigen expression in follicular lymphoma.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumors.

The paper identifies distinct cellular identities in low and high-risk neuroblastoma tumors using single-nuclei transcriptomes, linking them to clinical outcomes and age at diagnosis.

Multiomics Interrogation into HBV (Hepatitis B Virus)-Host Interaction Reveals Novel Coding potential in Human Genome, and Identifies Canonical and Non-canonical Proteins as Host Restriction Factors against HBV

Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

The paper identifies a 32-gene signature specific to Ewing sarcoma and shows that LOXHD1, a stereociliary protein, is a key driver of malignancy through its regulation by EWSR1-FLI1.

Identification of a peroxidase inhibitor that enhances kanamycin activity

The paper identifies a peroxidase inhibitor, 6D1, that enhances kanamycin activity against carbapenem-resistant bacteria.

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

Protoporphyrin IX and verteporfin prevent SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

A Novel Non-hypermucoviscous ST11 Hypervirulent Carbapenem-resistant Klebsiella pneumoniae Lacking Classical Virulence Factors

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

Mitofusin 2 regulates neutrophil adhesive migration via suppressing Rac activation

This study shows that Mitofusin 2 suppresses Rac activation to regulate neutrophil adhesive migration and actin cytoskeleton dynamics.

Lyb-2-4, a unique genomic region of hypervirulent carbapenem-resistant Acinetobacter baumannii

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

Serum-free culture system for spontaneous human mesenchymal stem cell spheroids formation

This study develops a serum-free method to generate human mesenchymal stem cell spheroids using knockout serum replacement, showing similar transcriptomes to FBS-based spheroids and retained MSC markers.

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration

The paper identifies miR-199 as a suppressor of neutrophil migration and inflammation by targeting CDK2, revealing a noncanonical role for CDK2 in cell polarity and chemotaxis.