K. Weber

On the ecology of Acinetobacter baumannii - jet stream rider and opportunist by nature

This study identifies white storks as a model system to explore the ecology of Acinetobacter baumannii, revealing its environmental reservoirs, seasonality, and genetic diversity across Europe.

Lysosomal MLKL is balanced by ESCRT to control cell death

The paper shows lysosomal MLKL is activated independently of RIPK3 and necroptosis, leading to cell death, which is counteracted by ESCRT machinery through lysosomal repair and sequestration of MLKL.

BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune CheckpointSensitivity in BRAFV600E-mutant Glioma

This study shows that BRAF/MEK inhibition induces cell state transitions in BRAFV600E-mutant gliomas, leading to PD-L1 upregulation and immune evasion, which can be overcome by combining with immune checkpoint inhibition.

Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment

This study identifies YAP1-driven collagen VI deposition in sarcoma as a mechanism suppressing CD8+ T cell function through ECM remodeling and autophagy inhibition.

Comparative oncology reveals DNMT3B as a therapeutic vulnerability in soft-tissue sarcoma

The paper identifies DNMT3B overexpression in UPS and shows its role in poor prognosis, but existing inhibitors are ineffective due to toxicity and uptake issues.

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

This study shows that confined migration in breast cancer cells increases metastatic potential by promoting resistance to anoikis and enhancing invasiveness.

Herbivore feeding behavior validates optimal defense theory for specialized metabolites within plants

The study shows that plants allocate specialized metabolites to tissues critical for fitness, influencing herbivore feeding behavior and supporting optimal defense theory.

Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

The paper identifies a 32-gene signature specific to Ewing sarcoma and shows that LOXHD1, a stereociliary protein, is a key driver of malignancy through its regulation by EWSR1-FLI1.

Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells via modulating metabolism and death pathways.

This study shows that low ANT1 expression in rhabdomyosarcoma cells promotes oncogenic properties by altering metabolism and death pathways, and restoring ANT1 sensitizes cells to chemotherapy.