Author

Z. Cramer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

N. Li· 5 shared Y. Tian· 5 shared C. J. Lengner· 4 shared M. S. Kim· 3 shared S. Adams-Tzivelekidis· 3 shared X. Wang· 3 shared B. W. Katona· 2 shared F. B. Johnson· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersCancer Biology

N. Li

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis

Z. Cramer, X. Wang, N. A. Leu, K. Monaghan, J. H. Rhoades, Y. Tian, J. Rico, D. Mendez, R. Petroni, M. S. Kim, R. Matsuda, M. F. Carrera, I. E. Brodsky, N. Li, C. J. Lengner, M. A. Blanco

The paper uses CRISPR/Cas9 screening in colorectal cancer organoids to identify novel metastasis regulators, finding Ctnna1 and Bcl2l13 as metastasis suppressors.

bioRxiv · Aug 3, 2023 · PreprintCancer Biology

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

N. Li, Q. Zhu, Y. Tian, K. J. Ahn, X. Wang, Z. Cramer, I. W. Folkert, P. Yu, J. Jou, S. Adams-Tzivelekidis, P. Sehgal, N. N. Mahmoud, C. B. Aarons, R. E. Roses, A. Thomas-Tikhonenko, , C. J. Lengner

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

bioRxiv · Sep 13, 2022Cancer Biology

APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer

Y. Tian, X. Wang, Z. Cramer, J. Rhoades, K. N. Estep, X. Ma, S. A. Tzivelekidis, B. W. Katona, F. B. Johnson, Z. Yu, M. A. Blanco, C. Lengner, N. Li

This study identifies NOTUM as a therapeutic target in advanced colorectal cancer, showing that its inhibition effectively arrests tumor growth and metastasis in models with APC and P53 mutations.

bioRxiv · Jul 26, 2022 · PreprintCancer Biology

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

N. M. Johnson, L. R. Parham, J. Na, K. E. Monaghan, H. M. Kolev, A. Klochkova, M. S. Kim, C. H. Danan, Z. Cramer, L. A. Simon, K. E. Naughton, S. Adams-Tzivelekidis, Y. Tian, P. A. Williams, N. A. Leu, , K. E. Hamilton

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

bioRxiv · Apr 8, 2022Cell Biology

Patient induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies

Y. Choi, M. S. Kim, J. H. Rhoades, N. M. Johnson, C. T. Berry, S. Root, Q. Chen, Y. Tian, R. J. Fernandez, Z. Cramer, S. Adams-Tzivelekidis, N. Li, F. B. Johnson, C. J. Lengner

The paper uses patient-derived iPS cells to model liver pathologies in telomeropathies and identifies AKT suppression as a potential therapeutic target.

bioRxiv · Nov 19, 2021Cell Biology

Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

Q. Deng, R. Natesan, F. Cidre-Aranaz, S. Arif, Y. Liu, R. Rasool, P. Wang, Z. Cramer, M. Chou, C. Kumar-Sinha, K. Weber, K. Eisinger-Mathason, N. Grillet, T. G. P. Grunewald, i. a. asangani

The paper identifies a 32-gene signature specific to Ewing sarcoma and shows that LOXHD1, a stereociliary protein, is a key driver of malignancy through its regulation by EWSR1-FLI1.

bioRxiv · Feb 22, 2021Cancer Biology