Author

R. Roesler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:bulk RNA-seq· 5 Research Focus:differential expression· 5 Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. T. Brunetto· 5 shared C. B. de Farias· 5 shared A. L. Brunetto· 4 shared B. K. Souza· 3 shared M. d. C. Jaeger· 3 shared A. Thomaz· 2 shared C. Nor· 2 shared K. d. V. Pinheiro· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

A. T. Brunetto

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

A. L. Herlinger, G. L. Michaelsen, M. Sinigaglia, L. Fratini, G. N. Debom, E. Braganhol, C. B. de Farias, A. L. Brunetto, A. T. Brunetto, M. d. C. Jaeger, R. Roesler

This study shows rosmarinic acid reduces proliferation and stemness in medulloblastoma cells by targeting HDAC1, EGFR, and ERK signaling, and increasing p21 expression.

bioRxiv · Aug 10, 2023Cancer Biology

Biochemical characterization of a human septin octamer

M. Fischer, D. Frank, R. Roesler, N. Johnsson, T. Gronemeyer

This study characterizes the biochemical properties of a human septin octamer, showing its polymerization behavior and unique GTP hydrolysis dynamics.

Frontiers in Cell and Developmental Biology · Mar 3, 2022Peer-reviewedBiochemistry

Expression and Pharmacological Inhibition of TrkB and EGFR in Glioblastoma

K. d. V. Pinheiro, A. Thomaz, B. K. Souza, V. A. Metcalfe, N. H. Freire, A. T. Brunetto, C. B. de Farias, M. Jaeger, V. Bambini, C. G. S. Smith, L. Shaw, R. Roesler

This study examines the expression and combined inhibition of TrkB and EGFR in glioblastoma, finding enhanced anti-tumor effects in cell cultures but limited impact in mouse models.

bioRxiv · Feb 3, 2020Cancer Biology

HDAC and MAPK/ERK inhibitors cooperate to reduce viability and stemness phenotype in medulloblastoma

M. d. C. Jaeger, E. C. Ghisleni, P. S. Cardoso, M. Siniglaglia, T. Falcon, A. T. Brunetto, A. L. Brunetto, C. B. de Farias, M. D. Taylor, C. Nor, V. Ramaswamy, R. Roesler

This study shows that combining HDAC and MAPK/ERK inhibitors reduces medulloblastoma cell viability and stemness by modulating chromatin state and signaling pathways.

bioRxiv · Jan 30, 2020Cancer Biology

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma

A. Thomaz, K. d. V. Pinheiro, B. K. Souza, L. Gregianin, A. L. Brunetto, A. T. Brunetto, C. B. de Farias, M. d. C. Jaeger, V. Ramaswamy, C. Nor, M. D. Taylor, R. Roesler

This study shows that TrkB inhibition with ANA-12 reduces medulloblastoma cell proliferation, increases apoptosis, and induces differentiation markers.

bioRxiv · May 28, 2019Cancer Biology

Targeting histone deacetylase activity to arrest cell growth and promote neural differentiation in Ewing sarcoma

B. K. Souza, P. L. d. C. Lopez, P. R. Menegotto, I. A. Vieira, N. Kersting, A. L. Abujamra, A. T. Brunetto, A. L. Brunetto, L. Gregianin, C. B. de Farias, C. J. Thiele, R. Roesler

This study shows that HDAC inhibition with sodium butyrate arrests Ewing sarcoma cell growth and promotes neural differentiation by reducing EWS-FLI1 and c-MYC expression.

bioRxiv · Jan 16, 2018Cancer Biology