M. Jaeger

Serum Proteome Profiling Identifies N-Cadherin and C-Met as Early Marker Candidates of Therapeutic Response to Neoadjuvant Chemotherapy in Breast Cancer

Proteomic discovery of chemical probes that perturb protein complexes in human cells

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

Light-inducible T cell engagers trigger, tune and shape the activation of primary T cells

The paper introduces a light-inducible T cell engager system to study how temporal TCR stimulation patterns influence T cell activation and cytokine responses.

The Immunological Factors Predisposing To Severe COVID-19 Are Already Present In Healthy Elderly And Men

The paper identifies immunological factors associated with severe COVID-19 in healthy elderly and men, showing intrinsic differences in immune cell subsets and inflammatory proteins.

Expression and Pharmacological Inhibition of TrkB and EGFR in Glioblastoma

This study examines the expression and combined inhibition of TrkB and EGFR in glioblastoma, finding enhanced anti-tumor effects in cell cultures but limited impact in mouse models.

Complement- and inflammasome-mediated autoinflammation-paroxysmal nocturnal hemoglobinuria

This study identifies AIF-PNH as a disease caused by germline and somatic mutations in PIGT, leading to complement activation and inflammasome-mediated IL-1β secretion, which is treatable with eculizumab.