M. Fischer

Comparison of the mechanism of antimicrobial action of the gold(I) compound auranofin in Gram-positive and Gram-negative bacteria

This paper investigates how auranofin affects Gram-positive and Gram-negative bacteria, finding that Gram-negative bacteria are more resistant due to efflux systems and glutathione levels.

Inactivation of the DREAM complex mimics the molecular benefits of sleep.

This study identifies the DREAM complex as a mediator of sleep and circadian benefits, showing that inhibiting DREAM can mimic sleep's cellular repair effects in sleep-deprived organisms.

Automated high-throughput selection of DNA aptamers using a common optical next-generation sequencer

This paper develops an automated high-throughput platform for DNA aptamer selection using an optical next-generation sequencer, achieving higher affinity aptamers in fewer rounds than conventional SELEX.

PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance

The paper identifies PRDX6 as an alternative pathway for selenocysteine metabolism that contributes to ferroptosis resistance in cancer cells.

METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma

This study shows METTL3 modifies TERRA lncRNA with m6A, promoting R-loop formation that targets TERRA to telomeres, and inhibiting METTL3 disrupts this process in ALT+ neuroblastoma cells.

Natural history of eukaryotic DNA viruses with double jelly-roll major capsid proteins

The paper uses protein structure modeling to analyze the evolutionary relationships and functional domains of eukaryotic DNA viruses with double jelly-roll capsids, revealing their origin and evolution.

One to rule them all? Assessing the performance of sustainable forest management indicators against multitaxonomic data for biodiversity conservation

The paper evaluates Forest Europe biodiversity indicators against multitaxonomic data, finding no single indicator captures overall biodiversity, but combinations perform better.

Old, broad-leaved stands support both high biodiversity and carbon storage in German forests

This study shows that older, broad-leaved forests in Germany support both high biodiversity and carbon storage, suggesting sustainable management strategies for Central Europe.

METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma

This study shows METTL3 and MYCN cooperate to maintain undifferentiated neural crest cells in neuroblastoma, and METTL3 inhibition promotes differentiation and chemosensitivity.

A fast-slow trait continuum at the level of entire communities

The paper shows that slow and fast functional strategies manifest at the ecosystem level, driven by disturbance and resource availability in grassland communities.

Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

This study shows resident macrophages improve cardiac remodelling while recruited macrophages influence infarct size after myocardial ischemia/reperfusion injury.

Functional synapses between small cell lung cancer and glutamatergic neurons

This study identifies glutamatergic synaptic interactions between SCLC cells and neurons, showing that these interactions support tumor growth and can be targeted therapeutically.

Canary in the Forest? Tree mortality and canopy dieback of western redcedar linked to drier and warmer summer conditions

This study links increased tree mortality and canopy dieback in western redcedar to drier and warmer summer conditions using tree-ring analysis across coastal and interior populations.

Biomechanical modeling of Border Collies (Canis familiaris) for insights of tail and limb use during the aerial phase of jumping

This study creates a biomechanical model of Border Collies during jumping to assess tail and limb inertial contributions, finding minimal inertial advantage from the tail.

Loss of species richness with land use intensity is explained by a reduction in niche differences.

The paper shows that land use intensity reduces species richness by decreasing niche differences, not competitive inequalities, and highlights the importance of stabilizing interactions for biodiversity.

Non-aging despite high mutation rate - genomic insights into the evolution of Hydra

This study examines Hydra's genome to understand its non-aging phenotype, finding no reduced mutation rate and identifying genes under selection related to regeneration and metabolism.

Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers

This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.

Therapeutic neutralizing monoclonal antibody administration protects against lethal viscerotropic Yellow Fever infection

Therapeutic monoclonal antibodies prevent death from YFV infection.

Biochemical characterization of a human septin octamer

This study characterizes the biochemical properties of a human septin octamer, showing its polymerization behavior and unique GTP hydrolysis dynamics.

Reversible brain edema in experimental cerebral malaria is associated with transcellular blood-brain barrier disruption and delayed microhemorrhages

This study identifies transcellular blood-brain barrier disruption as a mechanism for reversible brain swelling in experimental cerebral malaria, with implications for therapeutic strategies.

Parental environmental effects are common and strong, but unpredictable, in Arabidopsis thaliana

This study shows that parental environmental effects are common and strong in Arabidopsis thaliana but are genotype-dependent and unpredictable across different stress treatments.

MYCN mediates cysteine addiction and sensitizes to ferroptosis

This study shows MYCN promotes cysteine addiction and ferroptosis resistance in neuroblastoma, identifying therapeutic targets for ferroptosis induction.

pUL36 de-ubiquitinase activity augments both the initiation and progression of lytic virus infection in IFN-primed cells

This study shows that pUL36 DUB activity helps HSV-1 overcome IFN resistance and enhance lytic infection in IFN-primed cells.

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors.

This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.

SOX11 is a lineage-dependency factor and master epigenetic regulator in neuroblastoma

This study identifies SOX11 as a critical transcription factor and epigenetic regulator in adrenergic neuroblastoma, showing its role in chromatin accessibility and cell identity.

Assessing the impact of grassland management on landscape multifunctionality

This paper identifies optimal grassland compositions for ecosystem services using simulation and an online tool, showing that mixed intensity landscapes can maximize multifunctionality when services trade-off.

Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma

The paper identifies two distinct MYCN amplicon structures in neuroblastoma, showing how enhancer hijacking compensates for loss of local regulatory elements.

Plant traits are poor predictors of long-term ecosystem functioning

This study shows that plant traits poorly predict long-term ecosystem functioning, with only moderate explanatory power across years.

Rare species perform worse than common species under changed climate

This study transplants rare and common plant species to different climates and finds rare species have lower survival and biomass under novel conditions, especially when precipitation differs from their natural range.