Author

R. Ruhl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

S. Anand· 5 shared C. Espinosa-Diez· 4 shared A. Baris· 2 shared C. Hudson· 2 shared E. Fraile-Bethencourt· 2 shared R. Wilson· 2 shared S. Khou· 2 shared S. Rana· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

S. Anand

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tumor cell intrinsic RIG-I activation co-opts the host microenvironment to drive immune mediated tumor rejection

E. Fraile-Bethencourt, S. Khou, A. Baris, R. Ruhl, S. Anand

This study shows that activating RIG-I in tumor cells enhances anti-tumor immunity and improves response to checkpoint therapy, suggesting a strategy for cancer vaccines.

bioRxiv · Dec 21, 2022 · PreprintCancer Biology

DNA damage-induced lncRNA MEG9 impacts angiogenesis

E. Fraile-Bethencourt, S. Khou, R. Wilson, A. Baris, R. Ruhl, C. Espinosa-Diez, S. Anand

This study identifies MEG9 as a cytoprotective lncRNA in endothelial cells that modulates angiogenesis and vascular homeostasis in response to DNA damage.

bioRxiv · Dec 7, 2022 · PreprintCell Biology

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence and angiogenic signaling

C. Espinosa-Diez, R. Wilson, N. Chatterjee, C. Hudson, R. Ruhl, C. Hipfinger, E. Helms, O. F. Khan, D. G. Anderson, S. Anand

The paper shows that miR-494 and miR-99b regulate the MRN complex, affecting DNA repair, senescence, and angiogenesis through VEGF and CD44 pathways.

bioRxiv · Jan 18, 2018Cancer Biology

Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase

S. Rana, C. Espinosa-Diez, R. Ruhl, C. R. Thomas, S. Anand

This study shows that miR-15a regulates SMPD1 in endothelial cells, affecting angiogenesis and tumor growth in response to radiation.

bioRxiv · Jan 4, 2018Cancer Biology

MicroRNA-451a regulates colorectal cancer radiosensitivity

R. Ruhl, S. Rana, K. Kelley, C. Espinosa-Diez, C. Hudson, C. Lanciault, C. Thomas, L. V. Tsikitis, S. Anand

This study identifies miR-451a as a regulator of colorectal cancer radiosensitivity, showing it inhibits proliferation and enhances radiation response.

bioRxiv · May 9, 2017Cancer Biology