R. Wilson

Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque

This study delivers hIGF1-loaded nanoparticles to the placenta of a pregnant rhesus macaque via uterine artery catheterization, showing successful placental uptake and expression of hIGF1.

Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model

This paper demonstrates that placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model by improving fetal weight, blood glucose, and reducing cortisol levels.

Kinases in motion: impact of protein and small molecule interactions on kinase conformations

This study uses KinCon-reporter technology to analyze conformational changes in disease-associated kinases upon drug, regulatory protein, and pathway activation interactions, revealing insights into therapeutic strategies.

Heritable intraspecific variation among prey in size and movement interact to shape predation risk and potential natural selection

The paper examines how heritable variation in body size and movement traits of Paramecium caudatum affects predation risk by copepods, revealing independent selection pressures on these traits.

Optimizing CRE and PhiC31 mediated recombination in Aedes aegypti

This paper improves genetic manipulation techniques in Aedes aegypti by introducing transgenic lines for Cre-mediated recombination and a plasmid-based PhiC31 integrase system for stable transgene integration.

Assessment of Landbird Population Change in the Southeastern United States

This study assesses landbird population changes in the Southeastern United States and compares them to continental patterns, identifying key species and habitats most affected.

DNA damage-induced lncRNA MEG9 impacts angiogenesis

This study identifies MEG9 as a cytoprotective lncRNA in endothelial cells that modulates angiogenesis and vascular homeostasis in response to DNA damage.

Placental treatment with insulin-like growth factor 1 via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua

This study shows that hIGF-1 nanoparticle treatment differentially affects vascular remodeling factors in guinea pig sub-placenta/decidua under FGR and normal conditions.

Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific manner

This study shows that placental nanoparticle gene therapy with hIGF-1 reduces sex-specific gene expression changes in fetal livers of growth-restricted fetuses.

Cell overgrowth during G1 arrest triggers an osmotic stress response and chronic p38 activation to promote cell cycle exit

The paper shows that CDK4/6 inhibitor-induced G1 arrest causes cell overgrowth, triggering osmotic stress and p38-p53-p21 signaling to promote cell cycle exit.

Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats

This study examines how dopamine D1-like receptor agonists and antagonists affect nicotine and food intake and locomotor activity in male and female rats, finding no sex differences in their effects.

Cathelicidin-3 associated with serum extracellular vesicles enables early diagnosis of a transmissible cancer

The paper identifies cathelicidin-3 in serum extracellular vesicles as a biomarker for early diagnosis of DFTD in Tasmanian devils with high sensitivity and specificity.

Time mating guinea pigs by monitoring changes to the vaginal membrane throughout the estrus cycle and with ultrasound confirmation

The paper describes a method to time mating in guinea pigs by monitoring vaginal membrane changes and confirms pregnancy with ultrasound, achieving 100% success in a cohort.

Community composition exceeds area as a predictor of long-term conservation value

The paper shows that compositional distinctness is a better predictor of long-term species loss than site area in conservation prioritization.

Nanoparticle-mediated transgene expression of insulin-like growth factor 1 in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations

This study uses nanoparticle-mediated hIGF-1 gene therapy in a guinea pig model of FGR to increase placental nutrient transporter expression and fetal glucose concentrations.

Quantifying the Inhibitory Impact of Soluble Phenolics on Carbon Mineralization from Sphagnum-rich Peatlands

The paper investigates how soluble phenolics inhibit carbon mineralization in Sphagnum-rich peatlands by measuring CO2 and CH4 production under varying phenolic concentrations.

Microinductor-Fused Atomic Force Microscopy Cantilevers for Dynamic Imaging and Multimodal Manipulation

This paper introduces microinductor-fused AFM cantilevers that enhance imaging and manipulation capabilities by enabling simultaneous stiffness and friction mapping with improved compositional contrast.

Animal lifestyle changes acceptable mass limits for attached tags

The paper introduces a method to calculate acceptable tag mass limits for animals based on their movement patterns and athleticism, showing that 3% of body mass is not always sufficient.

Mapping social reward and punishment processing in the human brain: A voxel-based meta-analysis of neuroimaging findings using the Social Incentive Delay task

This study maps brain regions involved in social reward and punishment processing using a voxel-based meta-analysis of fMRI data from the Social Incentive Delay task.

Tasmanian devil facial tumour-derived extracellular vesicles reveal mesenchymal transition markers and adhesion molecules related to metastasis.

This study analyzes extracellular vesicles from Tasmanian devil cancers to identify markers of metastasis and differential aggressiveness between two cancer types.

Path tortuosity changes the transport cost paradigm in terrestrial animals

The paper shows that path tortuosity affects transport cost in terrestrial animals, with minimum cost of transport speed decreasing as tortuosity increases.

Stretched-Exponential Modeling of Anomalous T1{rho} and T2 Relaxation in the Intervertebral Disc In Vivo

This study applies stretched-exponential modeling to T1{rho} and T2 relaxation data in intervertebral discs to better detect matrix composition changes associated with degeneration.

A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae

This study identifies hemophilin, a heme-binding protein from Haemophilus haemolyticus, which inhibits non-typeable Haemophilus influenzae by heme starvation.

MYCN Amplification and ATRX Mutations are Incompatible in Neuroblastoma

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence and angiogenic signaling

The paper shows that miR-494 and miR-99b regulate the MRN complex, affecting DNA repair, senescence, and angiogenesis through VEGF and CD44 pathways.

Ancient hybridization and strong adaptation to viruses across African vervet monkey populations

This study analyzes genome-wide polymorphism in vervet monkeys to reveal ancient hybridization and strong adaptation to viruses, particularly SIV, across African populations.