R. Sakai

The paper shows that glucose uptake via GLUT1 co-endocytoses with PDGF receptor upon PDGF stimulation, delivering glucose to mitochondria for glycolysis.

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

This study identifies DGCC as a key lipid used by giant clams to thrive in nutrient-poor environments through symbiotic algae.

A marine sponge-derived lectin activates the thrombopoietin receptor by promoting dimerization and exhibits synergy with thrombopoietin, affecting receptor internalization.

This study identifies SIDT2 as a mediator of microautophagy that delivers cytosolic proteins into lysosomes, linking proteostasis to protein aggregation disease.

The paper develops a cyclo olefin polymer-based microphysiological system to improve drug screening and toxicological testing by avoiding material-related issues.

The paper develops a gut-liver-on-a-chip platform to model NAFLD and shows co-culturing gut and liver cells alters gene expression and lipid accumulation in response to free fatty acids.