K.-i. Kamei

This paper develops a hybrid adipocyte-derived exosome platform for targeted chemo-phototherapy of hepatocellular carcinoma, showing enhanced drug delivery and tumor growth inhibition.

This paper develops a nanomicelle, SANTA FE OXA, that enhances cancer chemotherapy by inducing ferroptosis and reducing systemic toxicity.

This study modifies a corneal epithelium-on-a-chip model to simulate dry eye syndrome by applying an air-liquid interface stimulus and assesses its effects with and without diclofenac.

This paper introduces a Brain Organoid-on-a-Chip platform that generates signaling gradients to create topographic forebrain organoids, mimicking human brain regions for neurodevelopment and disease studies.

The paper shows cyclic mechanical stretching enhances angiocrine signals like HGF and MMP9 in co-cultured hepatoblasts and endothelial progenitor cells during liver bud formation from hPSCs.

A non-cell-adhesive hydrogel enables blastoid formation from primed hPSC, mimicking blastocyst structure and differentiation.

This paper introduces a gut-liver-axis microphysiological system that applies physiologically relevant fluid shear stress to gut and liver cells, enhancing their survival and functional protein expression.

This paper introduces a simplified small molecule-based method to generate functional corneal epithelial cells from human pluripotent stem cells, showing improved differentiation and metabolic characteristics.

This study generates iPSCs from Grevy's zebra and compares their transcriptome to other mammalian PSCs, revealing evolutionary conservation and species-specific variation in pluripotency genes.

This study identifies a bi-phasic effect of gelatin on skeletal muscle regeneration through ROS-mediated signaling, showing low-dose gelatin promotes regeneration while high-dose inhibits it.

This study evaluates solvent use in microphysiological systems fabrication, showing that solvent bonding harms cell cultures while photobonding avoids these issues.

This study introduces Cornea-Chip to analyze spatiotemporal metabolite dynamics in corneal epithelium barriers using metabolomics and mRNA analysis.

This paper develops a COP-MPS in vitro model to study NAFLD by preventing FFA absorption, showing lipid accumulation and cell inactivation in HepaRG cells.

The paper develops an LC-MS-based untargeted metabolomics protocol to analyze micro-scale extracellular metabolites from hepatocytes and identifies metabolite shifts over time.

The paper develops a cyclo olefin polymer-based microphysiological system to improve drug screening and toxicological testing by avoiding material-related issues.

The paper develops a gut-liver-on-a-chip platform to model NAFLD and shows co-culturing gut and liver cells alters gene expression and lipid accumulation in response to free fatty acids.

The paper uses a microfluidic platform to simulate human heart beats, enhancing the functional properties of hepatoblasts derived from hepatic endoderm.

The paper analyzes the evolution of the pluripotency gene regulatory network across mammals, finding conservation in signaling pathways and rapid evolution in downstream targets.

This study shows that culturing hepatocyte-like cells from human embryonic stem cells at 39°C improves hepatic functions like albumin secretion and CYP3A4 activity without significant cell death.

This paper develops a microfluidic platform to simulate eye blinking shear stress on human corneal epithelial cells, showing enhanced barrier function under flow conditions.

The paper describes a method to generate self-organized blastocyst-like cysts from human pluripotent stem cells using a hydrogel matrix and identifies trophoblast and inner cell mass formation.

This paper develops a simple Liver-on-a-Chip platform using hPSC-derived hepatocyte-like cells, showing improved hepatic function and maturation.

This study identifies 18 positively selected genes in cetaceans related to lipid metabolism, showing divergent evolution from bovids and highlighting pathways involved in lipid digestion and energy production.