R. Schade

Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and to colonize humanized mice

This study shows that S. Typhi uses both T3SS-1 and T3SS-2 to replicate in human macrophages and colonize humanized mice, with functional redundancy between the systems.

Gut regulatory T cells mediate immunological tolerance in Salmonella Typhimurium-infected superspreader hosts by suppressing cytotoxic activity of T cells.

The paper identifies regulatory T cells (Tregs) as critical for maintaining immunological tolerance in superspreader hosts infected with Salmonella Typhimurium by suppressing cytotoxic T-cell activity.