D. M. Monack

Temporal profiling of Salmonella transcriptional dynamics during macrophage infection using a comprehensive reporter library

This study uses a GFP-reporter library to profile Salmonella transcriptional dynamics during macrophage infection, revealing condition-specific regulation and novel gene activity.

Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and to colonize humanized mice

This study shows that S. Typhi uses both T3SS-1 and T3SS-2 to replicate in human macrophages and colonize humanized mice, with functional redundancy between the systems.

Single-cell profiling identifies ACE+ granuloma macrophages as a non-permissive niche for intracellular bacteria during persistent Salmonella infection

The paper identifies ACE+ granuloma macrophages as non-permissive for intracellular Salmonella persistence using single-cell transcriptomics in mice.

Multi-omics reveal Salmonella-liberated dietary L-arabinose promotes expansion in superspreaders

The paper shows diet-derived L-arabinose promotes Salmonella expansion in superspreader hosts through a novel enzyme-mediated pathway.

Gut regulatory T cells mediate immunological tolerance in Salmonella Typhimurium-infected superspreader hosts by suppressing cytotoxic activity of T cells.

The paper identifies regulatory T cells (Tregs) as critical for maintaining immunological tolerance in superspreader hosts infected with Salmonella Typhimurium by suppressing cytotoxic T-cell activity.

Metabolomic analysis of diverse mice reveals hepatic arginase-1 as source of plasma arginase in Plasmodium chabaudi infection

The paper uses metabolomic analysis in diverse mice to show that liver damage during Plasmodium chabaudi infection releases hepatic arginase-1 into plasma, contributing to arginine depletion.

Adding function to the genome of African Salmonella ST313

The paper compares genomic and transcriptomic differences between Salmonella ST313 and ST19 isolates to identify phenotypic variations and a novel plasmid maintenance system.