Author

R. Shroff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Ellington· 2 shared A. C. Maranhao· 1 shared A. Cole· 1 shared A. D. Ellington· 1 shared A. Kolomeisky· 1 shared B. Alexander· 1 shared B. R. Morrow· 1 shared C. J. Zhu· 1 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBioengineering

A. Ellington

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Deep learning redesign of PETase for practical PET degrading applications

H. Lu, D. J. Diaz, N. J. Czarnecki, C. J. Zhu, W. Kim, D. J. Acosta, B. Alexander, R. Shroff, H. Cole, Y. J. Zhang, N. Lynd, A. D. Ellington, H. S. Alper

This paper uses deep learning to redesign PETase, creating a highly active and stable enzyme for efficient PET degradation and industrial recycling.

bioRxiv · Oct 10, 2021 · PreprintBioengineering

DLPacker: Deep Learning for Prediction of Amino Acid Side Chain Conformations in Proteins

M. Misiura, R. Shroff, R. Thyer, A. Kolomeisky

The paper introduces a deep learning method for predicting amino acid side chain conformations, showing significant improvements over existing physics-based methods.

bioRxiv · May 23, 2021Biophysics

Multi-modal engineering of Bst DNA polymerase for thermostability in ultra-fast LAMP reactions

I. Paik, P. H. T. Ngo, R. Shroff, A. C. Maranhao, D. J. F. Walker, S. Bhadra, A. Ellington

This paper engineers Bst DNA polymerase for improved thermostability and ultra-fast LAMP performance through multimodal rational design methods.

bioRxiv · Apr 15, 2021 · PreprintBioengineering

Evolving Bacterial Fitness with an Expanded Genetic Code

D. Tack, A. Cole, R. Shroff, B. R. Morrow, A. Ellington

This study evolves bacteria to use a 21 amino acid genetic code by incorporating an ambiguous amber codon encoding either 3-nitro-L-tyrosine or stop, revealing transitional intermediates in genetic code expansion.

bioRxiv · Jul 28, 2017Evolutionary Biology